Living ~400lbs

… and believe me I am still alive

Vitamin B12 in the news

I’ve written about my vitamin B12 absorption problem before.  The NY Times recently posted a good primer on B12 deficiencies, including those at risk:

Natural plant sources are meager at best in B12, and the vitamin is poorly absorbed from them. […C]hronic users of acid-suppressing drugs like Prilosec, Prevacid and Nexium, as well as ulcer medications like Pepcid and Tagamet, are at risk of developing a B12 deficiency and often require a daily B12 supplement.

Stomach acid levels decline with age. As many as 30 percent of older people may lack sufficient stomach acid to absorb adequate amounts of B12 from natural sources. […]

Synthetic B12, found in supplements and fortified foods, does not depend on stomach acid to be absorbed. But whether natural or synthetic, only some of the B12 consumed gets into the body. Treatment to correct a B12 deficiency typically involves much larger doses than the body actually requires.

Free B12 from both natural and synthetic sources must be combined with a substance in the stomach called intrinsic factor to be absorbed through the gut. This factor is lacking in people with an autoimmune disorder called pernicious anemia; the resulting vitamin deficiency is commonly treated with injections of B12.

Although most doctors are quick to recommend injections to correct a B12 deficiency, considerable evidence indicates that, in large enough doses, sublingual (under-the-tongue) tablets or skin patches of B12 may work as well as injections for people with absorption problems, even for those with pernicious anemia.

The latter is something I make use of — I appear not to absorb much B12 from food, but the little I absorb of  “a lot” is enough.  I also like that supplements are over-the-counter and I can take them daily.  Shots would be prescription and often weekly or monthly.  :)

3 responses to “Vitamin B12 in the news”

  1. Mmm, interesting. My mother and sister both have pernicious anemia and both get shots of B12 regularly, my mother requires them more often since she turned 70. I might suggest supplementation in addition. Thanks for the information.

  2. With autoimmune pernicious anemia, there are two types of intrinsic factor antibodies. One kind lets you absorb some b12 from pills by mass absorption in the small intestine, the other actually blocks the ileal receptors from absorbing the B12-IF complex. People can have type 1 only, or type 1 and 2. So if you have type 2, you can only absorb B12 via injections. I give myself an injection about every 1-2 weeks, as I go by symptoms only, the serum b12 blood test is actually pretty unreliable. (Also iinjectable b12 is over-the-counter here in Australia.)

  3. Don’t forget that taking metformin (Glucophage) also puts a person at risk for B12 deficiencies over time.

    People on metformin should have their B12 levels (and perhaps folate levels) monitored regularly.

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About Me

Former software tester, now retired heart patient having fun and working on building endurance and strength. See also About page.

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